- An Examination of the Anti-fungal Components in the Heartwood Extracts
of Pterocarpus indicus.
Mokuzai gakkaishi, 41 , 593-597 (1995).
C. Pilotti, R. Kondo, K. Shimizu and K. Sakai
- A Stilbene Derivative from Artocarpus incisus.
Phytochemistry 45(6), 1297-1298 (1997)
K. Shimizu, R. Kondo and K. Sakai
- The Inhibitory Components from Artocarpus incisus on Melanin Biosynthesis.
Planta Med. 64, 408 - 412 (1998)
K. Shimizu, R. Kondo, K. Sakai, S.-H. Lee and H. Sato
- Inhibition of tyrosinase by flavonoids, stilbenes and related 4-substituted
resorcinols: Structure-activity investigations.
Planta Med. 66, 11-15 (2000)
K. Shimizu, R. Kondo and K. Sakai
- The 5α-reductase inhibitiory components from heartwood of Artocarpus incisus:
Structure-activity investigations.
Planta Med. 66, 16-19 (2000)
K. Shimizu, M. Fukuda, R. Kondo and K. Sakai
- The 5α-reductase inhibitory activity and hair regrowth effects of extract
from Boehmeria nipononivea.
Biosci. Biotechnol. Biochem. 64, 875-877 (2000)
K. Shimizu, R. Kondo, K. Sakai, Y. Shoyama, H. Sato and T. Ueno
- The 5α-reductase inhibitory component from leaves of Artocarpus altilis.
J. Wood. Sci. 46, 385-389 (2000)
K. Shimizu, R. Kondo, K. Sakai , S. Buabarn, U. Dilokkunanant
- A geranylated chalcone with 5α-reductase inhibitory properties from Artocarpus incisus.
Phytochemistry 54, (8) 737-739 (2000)
K. Shimizu, R. Kondo and K. Sakai
- Novel vitamin E derivative with 4-substituted resorcinol moiety has both
antioxidant and tyrosinase inhibitory properties.
Lipids 36, 1321-6 (2001)
K. Shimizu, R. Kondo, K. Sakai, N. Takeda, T. Nagahata, T. Oniki
- The skin-lightening effects of artocarpin on UVB -induced pigmentation.
Planta Med. 68, 79-81(2002)
K. Shimizu, R. Kondo, K. Sakai, N. Takeda and T. Nagahata
- Antioxidant activity of heartwood extracts of Papua New Guinean woods.
J. Wood. Sci. 48, 446-450 (2002)
K. Shimizu, R. Kondo, K. Sakai
- Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells
Planta Med. 68, 995-998 (2002)
K. Towatari, K. Yoshida, N. Mori, K. Shimizu, R. Kondo, K. Sakai
- The morphological feature and dietarily functional components in fruit-bodies
of two strains of Pholiota adiposa grown on artificial beds
J. Wood. Sci. 49: 193-196 (2003)
K. Shimizu, R. Fujita, R. Kondo, K. Sakai, S. Kaneko
- Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185.
J. Wood Sci. 49: 349-354 (2003)
K. Shimizu, X. Geng, M. Hashiguchi, H. Suhara, S. Fukunaga, S. Yasutake,
R. Kondo, M. Tsutsui, I. Sato
- A New Stilbene with Tyrosinase Inhibitory Activity from Chlorophora excelsa
Chem. Pharm. Bull. 51(3) 318-319 (2003)
K. Shimizu, S. Yasutake, R. Kondo
- entIsopimarane diterpenoids of the leaves from Rabdosia forrestii
Fitoterapia 74 (7-8):649-9 (2003)
I. Kubo, K. Shimizu, Y.L. Xu
- Arudonine, an allelopathic steroidal glycoalkaloid from the root bark of
Solanum arundo Mattei
Phytochemistry 65 (9) 1283-6 (2004)
K. Fukuhara, K. Shimizu, I. Kubo
- Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii.
Phytother Res.18 (2): 180-3(2004)
I. Kubo, Y Xu, K Shimizu
- Oxidation products of quercetin catalyzed by mushroom tyrosinase
Bioorg. Med. Chem. 12:5343-5347(2004)
I kubo, K. Nihei,K. Shimizu
- Resveratrol oligomers from the stem bark of Hopea bancana (Dipterocarpaceae)
Bull. Soc. Nat. Prod. Chem. (Indonesia) 4:17-22 (2004)
Tukiran, Sjamsul A. Achmad, Euis H. Hakim, Yana M. Syah, Lukman Makmur,
Lia D. Juliawaty, K. Shimizu, K. Sakai
- The effect of strain, growth stage and cultivationg condition of Ganoderma lucidum on 5a-reductase inhibition
J. Wood Sci.. 51(2), 189-192 (2005)
J. Liu, R. Fujita, M. Sato, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto,
C. Ueda, H. Tajiri, S. Kaneko, Y. Suimi, R. Kondo
- Screening of Indonesian plants for tyrosinase inhibitory activity
J. Wood Sci.. 51(5), 520-525(2005)
Enos T. Arung, Irawan W. Kusuma, Yetti M. Iskandar, S. Yasutake, K. Shimizu,
R. Kondo
- Oligostilbenoids from the stem bark of Shorea selanica Blume (Dipterocarpaceae)
Tukiran, S.A. Achmad, E.H. Hakim, Y.M. Syah, L. Makmur, L.D. Juliawaty,
K. Shimizu, and K. Sakai.
Malaysian Journal of Science (MJS), 24 (1), 27-35 (2005)
- Oligostilbenoids from Shorea balangeran.
Biochemical systematic and Ecology (BSE), 33, 631-634(2005)
Tukiran, S.A. Achmad, E.H. Hakim, L. Makmur, K. Sakai, K. Shimizu, and
Y.M. Syah
- The effect of chlorophorin and its derivatives on melanin biosynthesis.
Holzforschung 59, 514-518 (2005)
Enos T. Arung, K. Yoshikawa., K. Shimizu, R. Kondo
- Anti-androgenic activities of Ganoderma lucidum.
J. Ethnopharmacol. 102, 107-112 (2005)
R. Fujita, J. Liu, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, C. Ueda,
H. Tajiri, S. Kaneko, Y. Suimi, R. Kondo
- 5a-reductase inhibitory effects of triterpenoids isolated from Ganoderma lucidum.
Biol. Pharm. Bull. 29, 392-395 (2006)
J. Liu, K. Kurashiki, K. Shimizu, R. Kondo
- Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
Food Chem. 100, 1691-1696 (2007)
J. Liu, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, K. Kurashiki, R.
Kondo
- Ganoderic acid TR, a new lanostanoid with 5a-reductase inhibitory activity from the fruiting body of Ganodema lucidum.
Nat. Prod. Commun. 1(5) 345-350 (2006)
J. Liu, K. Shimizu, R. Kondo
- Estrogen-like activity and prevention effect of bone loss in calcium deficient
ovariectomized rats by the extract of Pleurotus eryngii.
Phytother. Res. 20, 659-664 (2006)
K. Shimizu, M. Yamanaka, M. Gyokusen, S. Kaneko, M. Tsutsui, J. Sato, I.
Sato, M. Sato, R. Kondo
- Inhibitory Effect of Isoprenoid-substituted Flavonoids Isolated from Artocarpus heterophyllus on Melanin Biosynthesis
Planta Med 72, 847-850 (2006)
Enos T. Arung, K. Shimizu, R. Kondo
- Inhibitory effect of Artocarpanone from Artocarpus heterophyllus on melanin biosynthesis
Biol Pharm. Bull. 29, 1966-1969 (2006)
Enos T. Arung, K. Shimizu, R. Kondo
- Hemsleyanoside F, an oligoresveratrol glucoside from the stem bark of Shorea parvistipulata F. Heim.
Bull. Soc. Nat. Prod. Chem. (Indonesia) 6, 7-12 (2006)
Tukiran, K. Sakai, K. Shimizu, S.A. Achmad
- Screening of extracts of Japanese woods for melanin biosynthesis inhibition
- Structure activity relationship for inhibition of 5α-reductase by triterpenoids
isolated from Ganoderma lucidum
- Briononic acid from the hexane extract of Sandoricum koetjape Merr. stem bark (Meliaceae)
Indo. J. Chem. 6(3), 304-306 (2006)
Tukiran, Saidah, Suyatno, Nurul Hidayati, K Shimizu
- Steroid 9a-hydroxylation during testosterone degradation by resting Rhodococcus equi Cells
Arch. Pharm. Chem. Life Sci.. 340, 209-214 (2007)
Y. Kim, J. Han, S. S. Lee, K. Shimizu, Y. Tsutsumi, R. Kondo
-
The anti-androgen effect of ganoderol B isolated from the fruiting body
of Ganoderma lucidum
Bioorg. Med. Chem. 15 (14),4966-4972 (2007)
J. Liu, K. Shimizu, F. Konishi, S. Kumamoto, R. Kondo
- Isoprenoid-substituted polyphenols from Artocarpus heterophyllus -Melanin biosynthesis inhibitory activity and structural criteria-
Chem. Biodiversity, 4, 2166-2171 (2007)
Enos T. Arung, K. Shimizu, R. Kondo
-
Steroid 5α-reductase inhibitory activity of condensed tannins from woody
plants
J. Wood Sci 54(1), 68-75 (2008)
J. Liu, R. Ando, K. Shimizu, K. Hashida, R. Makino, S. Ohara, R. Kondo
- Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: A double-blaind, placebo-controlled
randomized and dose-ranging study
Asian J. Androl. 10(4), 651-8 (2008)
M. Noguchi, T. Kakuma, K. Tomiyasu, Y. Kurita, H. Kukihara, F. Konishi,
S. Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka
- Artocarpin, a promising compound as whitening agent and skin cancer
Journal of Wood Science and Technology, 6. 33-36 (2008)
Enos. T. Arung, S. Muladi, E. Sukaton, K. Shimizu, R. Kondo
- The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum
Phytother. Res., 23, 28-32 (2009)
S. Fatmawati, K. Kurashiki, S. Takeno, Y. Kim, K. Shimizu, M. Sato, K. Imaizumi, K. Takahashi, S. Kamiya, S. Kaneko, R. Kondo
- A randamized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms
Asian J. Androl.10 (5), 777-785 (2008)
M. Noguchi, T. Kakuma, K. Tomiyasu, A. Yamada, K. Itoh, F. Konishi, S.
Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka
- Essential Oil of Lavender Inhibited the Decrement of Attention
in the Long-term Task in Human
Biosci. Biotechnol. Biochem. 72, 1944-1947 (2008)
K. Shimizu, M. Gyokusen, S. Kitamura,T. Kawabe, T. Kozaki, K. Ishibashi,
R. Izumi, W. Mizunoya, K. Ohnuki, R. Kondo
- An extract of ganoderma lucidum in men with lower urinary tract symptoms:
A double-blind, placebo-controlled randomized and dose-ranging study
Nishinihon Journal of Urology 70(9), 466-472 (2008)
M..Noguchi, K. Tomiyasu, M, Nakiri, K. Matsuoka, T. Kakuma, F. Konishi,
S. Kumamoto, K. Shimizu, R. Kondo
- Anti-androgen effects of extracts and compounds from Ganoderma lucidum
Chem. Biodiversity, 6, 231-243 (2009)
J. Liu, S. Tamura, K. Kurashiki, K. Shimizu, K. Noda, F. Konishi, S. Kumamoto,
R. Kondo
- Estrogen-like activity of ethanol extract of Ganoderma lucidum
J. Wood Sci., 55, 53-39 (2009)
K. Shimizu, I. Miyamoto, J. Liu, F. Konishi, S. Kumamoto, R. Kondo
- Anti-androgenic activity of fatty acids
Chem. Biodiversity, 6, 503-512 (2009)
J. Liu, K. Shimizu, R. Kondo
- Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum
Eur. J. Pharmacol. 602 (1), 1-7(2009)
I. Miyamoto, J. Liu, K. Shimizu, A. Kukita, T. Kukita, M. Sato, R. Kondo
- Evaluation of biological activities of extracts from 22 African tropical
wood species
J. Wood Sci, 55 (3), 55, 225-229 (2009)
Z. Huang, K. Hashida, R. Makino, F. Kawamura, K. Shimizu, R. Kondo, S.
Ohara
- Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor
Bioorg. Med. Chem. Lett. 19, 2154-2157 (2009)
J. Liu, J. Shiono, K. Shimizu, A. Kukita, T. Kukita, R. Kondo
- 20(R)-Ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity
Bioorg. Med. Chem. Lett. 19, 3320-3323 (2009)
J. Liu, J. Shiono, K. Shimizu, H. Yu，C. Zhang, F. Jin, R. Kondo
- Provenance variation in growth and wood properties of A. mangium and A. auriculiformis in Central Java, Indonesia : selecting potential hybrid parents for good
performance
Bull. Kyushu Univ. For., 90, 25-37 (2009)
M. Hasegawa, R. Wakimoto, E. Yoshida, K. Shimizu, R. Kondo, A. Widyatmoko,
A. Nirsatmanto, S. Shiraishi
- Evaluation of medicinal plants from Central Kalimantan for anti melanogenesis
J. Nat. Med. 63, 473-480 (2009)
E. T. Arung, I. W. Kusuma, E. O. Christy, K. Shimizu, R. Kondo
- Ganoderic acids from Ganoderma lucidum. Inhibitory activity of osteoclastic differentiation and structural criteria
Planta Med. 76, 137-139 (2010)
J. Liu, J. Shiono, K. Shimizu, R. Kondo
- Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cell -Cytotoxicity and structural criteria-
Fitoterapia, 81, 120-123 (2010)
E. T. Arung, K. Yoshikawa, K. Shimizu, R. Kondo
- Methyl ganoderic acid DM: a selective potent osteoclastgenesis inhibitor
The Open Bioactive Compounds Journal, 2, 37-42 (2009)
J. Liu, J. Shiono, Y. Tsuji, K. Shimizu, R. Kondo
- Screening of extracts of Japanese medicinal plants for HMG-CoA reductase
inhibition
Res. Bull. Kagoshima Univ. For., 37, 37-41 (2010)
S. Yokoyama, S. Takeno, T. Nagata, K. Shimizu, R. Kondo
- Lipoxygenase inhibitory activity of 6-pentqadecanylsalicylic acid without
prooxidant effect
Natural Product Communications, 5(1), 85-90 (2010)
I. Kubo, T.J. Ha, K. Shimizu
- Antioxidant Activity and Cytotoxicity of the Traditional Indonesian Medicine
Tahongai (Kleinhovia hospita L.) Extract
JAMS Journal of Acupuncture and Meridian Studies, 2(4), 306-308 (2009)
E.T. Arung, I.W. Kusuma, S. Purwatiningsih, S.-S. Roh, C.H. Yang, S. Jeon,
Y.-U. Kim, E. Sukaton, J. Susilo, Y. Astuti, B.D. Wicaksono, F. Sandra,
K. Shimizu, R. Kondo.
- Antidermatophyte and antimelanogenesis compound from Eleutherine americana growing in Indonesia
J. Nat. Med. 64(2) 223-6(2010)
I. W. Kusuma, E. T. Arung, E. Rosamah, S. Purwatiningsih, H. Kuspradini,
Syafrizal, J. Astuti, Y-U, Kim, K. Shimizu
- Inhibition mode of soybean lipoxygenase-1 by quercetin
Chem. Biodiversity,7(8)1893?1903(2010)
T.J. Ha, K. Shimizu, T. Ogura, I. Kubo
- Tyrosinase inhibitory effect of quercetin 4'-O-b-glucopyranoside from dried skin of Red Onion (Allium cepa)
Natural Product Research, 25(3)256-263(2011)
E. T. Arung, K. Shimizu, I. W. Kusuma, R. Kondo.
- Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum
Planta Med.76: 1691-1693 (2010)
S. Fatmawati, K. Shimizu, R. Kondo
- 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory
activity from wood of Artocarpus heterophyllus
Fitoterapia., 81(6), 640-643 (2010)
E. T. Arung, K. Shimizu, H. Tanaka, R. Kondo.
- Cytotoxic effect of artocarpin on T47D cells
J. Nat. Med. 64(4), 423-429 (2010)
E. T. Arung, B. D. Wicaksono, Y. A. Handoko, I. W. Kusuma, K. Shimizu,
D. Yulia, F. Sandra
- Melanin biosynthesis inhibitors from wood of Artocarpus heterophyllus: The effect of isoprenoid substituent of flvone with 4-substituted resorcinol
moiety at B ring
Lett. Drug Des. Discovery, 7(8), 602-605 (2010)
E. T. Arung, K. Shimizu, H. Tanaka, R. Kondo
- Stereospecificity of hydroxyl group at C-20 in antiproliferative action
of ginsenoside Rh2 on prostate cancer cells
Fitoterapia., 81(7), 902-5(2010).
J. Liu, K. Shimizu, H. Yu，C. Zhang, F. Jin, R. Kondo
- The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells
Fitoterapia., 81(8), 1067?1072 (2010)
J. Liu, K. Shimizu, R. Kondo
- Ganoderic acid Df, a new triterpenoid with aldose reductase activity from
the fruiting body of Ganoderma lucidum
Fitoterapia., 81: 1033-1036 (2010)
S. Fatmawati, K. Shimizu, R. Kondo
- Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
Biomedical Research, , 31(4), 231-237(2010)
M. Nagano, K. Shimizu, R. Kondo, C. Hayashi, D. Sato, K. Kitagawa, K. Ohnuki
- Anti-melanogenesis properties of quercetin- and its derivative-rich extract
from Allium cepa
Food Chemistry, 124, 1024-1028 (2010)
E. T. Arung, S. Furuta, H. Ishikawa, I. W. Kusuma, K. Shimizu, R. Kondo
- Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells
Fitoterapia, 82(2)198-202(2011).
E. T. Arung, E. Matsubara, I. W. Kusuma, E. Sukaton, K. Shimizu, R. Kondo
- Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task
Biomedical Research, 32(1), 19-28 (2011)
E. Matsubara, M. Fukagawa, T. Okamoto, A. Fukuda, C. Hayashi, K. Ohnuki,
K. Shimizu, R. Kondo
- The essential oil of Abies sibirica (Pinaceae) reduces arousal levels after visual display terminal work
Flavour and Fragrance Journal, 26(3), 204-210 (2011)
E. Matsubara; M. Fukagawa; T. Okamoto; K. Ohnuki; K. Shimizu; R. Kondo
- (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level
after visual display terminal work without any influences of task performance
in low-dose condition
Biomedical Research, 32(2), 151-157 (2011)
E. Matsubara, M. Fukagawa, T. Okamoto, K. Ohnuki, K. Shimizu, R. Kondo
- Evaluation of biological activities of extracts from the fruiting body
of Pleurotus citrinopileatus for skin cosmetics
Journal of Wood Science, 57 (5), 452-458 (2011)
T.X. Meng, S. Furuta, S. Fukamizu, R. Yamamolto, H. Ishikawa, E.T. Arung,
K. Shimizu, S. Ohga, R. Kondo
- Ganoderol B: a potent a-glucosidase inhibitor isolated from the fruiting
body of Ganoderma lucidum
Phytomedicine., 18(12), 1053-5(2011).
S. Fatmawati, K. Shimizu, R. Kondo
- Antibacterial activity of moso bamboo shoot skin (Phyllostachys pubescens) against Staphylococcu aureus
Journal of Wood Science, 57(6), 542-544(2011)
A. Tanaka, H.J. Kim, S. Oda, Shimizu, R. Kondo
- A glucosylceramide with antimicrobial activity from the edible mushroom
Pleurotus citrinopileatus
Journal of Wood Science, 58(1), 81-86(2012)
T. X. Meng, H. Ishikawa, K. Shimizu, S. Ohga, R. Kondo
- Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3’-O-β-D-glucoside isolated from Allium cepa
Z. Naturforsch. 66 c, 209- 214 (2011)
E. T. Arung, S. Furuta, H. Ishikawa, H. Tanaka, K.i Shimizu, and R. Kondo
- Antioxidantive compounds from leaves of Tahongai (Klienhovia hospita)
Journal of Wood Science, 58(1)77-80 (2012)
E. T. Arung, I. W. Kusuma, Y.-U. Kim, K. Shimizu, R. Kondo
- Validation of Eupatorium triplinerve Vahl leaves, a skin care herbal from East Kalimantan in melanin biosynthesis
assay
Journal of Acupuncture and Meridian Studies, 5(2)87-92 (2012)
E. T. Arung, H. Kuspradini I. W. Kusuma, K. Shimizu, R. Kondo
- Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors
Bioorganic & Medicinal Chemistry Letters, 21, 7295-7297 (2011)
S. Fatmawati, K. Shimizu, R. Kondo
- Quantitative determination of the representative triterpenoids in the extracts
of Ganoderma lucidum with different growth stages using high-performance liquid chromatography
for evaluation of their 5α-reductase inhibitory properties
Food Chemistry, 133, 1034-1038 (2012)
J. Liu, K.i Kurashiki, A. Fukuta, S. Kaneko, Y. Suimi, K. Shimizu, R. Kondo
- Combination effect of miconazole with polygodial against Candida albicans
Open Journal of Medical Microbiology, 1, 7-11 (2011)
I. Kubo, S. H. Lee, K. Shimizu
- Antioxidant activity of compounds from wood of Artocarpus heterophyllus
Indonesian Journal of Pharmaceutical Sciences, 9(2) 72-77 (2011)
E. T. Arung and K. Shimizu
- The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells
Natural Products Communications, 7(8)1007-1010(2012)
E. T. Arung, S. Furuta, K. Sugamoto, K. Shimizu, H. Ishikawa, Y. Matsushita,
R. Kondo
- The melanin biosynthesis stimulating compounds isolated from the fruiting
bodies of Pleurotus citrinopileatus
Journal of Cosmetics, Dermatological Sciences and Applications, 2, 151-157
(2012)
T.-X. Meng, C.-F. Zhang, T. Miyamoto, H. Ishikawa, K. Shimizu, S Ohga,
R. Kondo
- Osteoclastogenesis inhibitory effect of ergosterol peroxide isolated from
Pleurotus eryngii
Natural Products Communications, 7(9)1163-1164 (2012)
S. Yokoyama, T. H. Bang, K. Shimizu, R. Kondo
- Volatiles emitted from the roots of Vetiveria zizanioides suppress the decline in attention during a visual display terminal task
Biomedical Research, 35(5)299-308 (2012)
E. Matsubara, K. Shimizu, M. Fukagawa, Y. Ishizi, C. Kakoi, T. Hatayama,
J. Nagano, T. Okamoto, K. Ohnuki, R. Kondo
- An ester of 4-methoxy cynnamic acid isolated from Xylocarpus moluccencis (Lamk) M. Roem (Meliaceae)
Indonesian Journal of chemistry, 12(2)184-188 (2012)
Tukiran, S. S. Cahyasari, K. Shimizu
- Target proteins of ganoderic acid DM provides clues to various pharmacological
mechanisms
Sci. Rep. 2, 905; DOI:10.1038/srep00905 (2012).
J. Liu, K. Shimizu, A. Tanaka, W. Shinobu, K. Ohnuki, T. Nakamura, R. Kondo.
- Antibacterial compounds from shoot skins of moso bamboo (Phyllostachys pubescens)
Journal of Wood Science, 59(2)155-159 (2013),
A. Tanaka, K. Shimizu, R. Kondo
- Corncobs as a Potential Source of Functional Chemicals
Molecules 2013, 18(11), 13823-13830; doi:10.3390/molecules181113823
A. Ashour, M. Amer, A.i Marzouk, K. Shimizu, R. Kondo and S. El-Sharkawy
- A protocol for isolation of target proteins of natural compound
J. Liu, K. Shimizu, A. Tanaka, W. Shinobu, K. Ohnuki, T. Nakamura &
R. Kondo
Protocol Exchange (2013) doi:10.1038/protex.2013.051
- Biotransformation of Khellin to Khellol by Aspergillus niger and the Evaluation of their Biological Activities.
A. Ashour, S. El-Sharkawy, M. Amer, F.A. Bar, A. Mera, T. Nagata, R. Kondo,
K. Shimizu, The Open Bioactive Compounds Journal, 4, 1-3 (2013)
DOI: 10.2174/1874847320130628001
- Comparative Biological Study of Roots, Stems, Leaves, and Seeds of Angelica shikokiana Makino.
Journal of Ethnopharmacology 148, 980-987 (2013)
A. Mira, A. Tanaka , Y. Tateyama, R. Kondo, K. Shimizu
- Wild Mushroom in Nepal: Some potential Candidates as Antioxidant and ACE Inhibition Sources
Evidence-Based Comprementary and Alternative Medicine, Volume 2014(2014),
Airticle ID 195305, 11 pages
T. H. Bang, H. Suhara, K. Doi, H. Ishikawa, K. Fukami, G. P. Parajuli, Y. Katakura, S. Yamashita, K. Watanabe, M. K. Adhikari, H. K. Manandhar, R. Kondo, K. Shimizu
- The Inhibitory Effect of Loquat Leaves (Eriobotrya japonica) on Ovariectomy-induced Bone Loss and Osteoclast Differentiation
Journal of Agricultural and Food Chemistry 62(4)836-41(2014)
H. Tan, S. Furuta, T. Nagata, K. Ohnuki, T. Akasaka, B. Shirouchi, M. Sato, R. Kondo, K. Shimizu
- Effects of isolated compound from Sonneratia caseolaris leaf : a validation of traditional utilization by melanin biosynthesis and antioxidant assays
Journal of Applied Pharmaceutical Science, 5(10): 39-43 (2015)
E. T. Arung, H. Kuspradini, I. W. Kusuma, T. H. Bang, S. Yamashita, Y.
Katakura, K. Shimizu
- Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors
Bioorganic & Medicinal Chemistry Letters, 23(21)5900-5903(2013)
S. Fatmawati, R. Kondo, K. Shimizu
- Rational design and synthesis of topoisomerase I and II inhibitor based
on olenanolic acid moiety for new anti-cancer drugs
Bioorganic & Medicinal Chemistry, 22(1)211-20(2013)
A. Ashour, S. El-Sharkawy, M. Amer, F.A. Bar, T. Miyamoto, N. Toyota, T.
H. Ban, R. Kondo, K. Shimizu.
- Biological activities and phytochemical profiles of extracts from different
parts of bamboo (Phyllostachys pubescens)
Molecules 2014, 19(6), 8238-8260; doi:10.3390/molecules19068238
A. Tanaka, Q. Zhu, H. Tan, H. Horiba, K. Ohnuki, Y. Mori, R. Yamauchi, H. Ishikawa, A. Iwamoto, H. Kawahara, K. Shimizu
- Hypotensive effects of Reishi (Ganoderma lingzhi)’s auto-digested extract and its potent peptides for Angiotensin-Converting
Enzyme inhibition.
Molecules 2014, 19, 13473-13485; doi:10.3390/molecules190913473
T. H. Bang, A. Yamamoto, S. Matsumoto, H. Ito, K. Igami, T. Miyazaki, R.
Kondo, K. Shimizu
- Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from unused
parts of Ammi visinaga
Journal of Cosmetics, Dermatological Sciences and Applications, Vol.3 No.3B
40-43 (2013)
A. Ashour, S. El-Sharkawy, M. Amer, F. A.l Bar, R. Kondo, K. Shimizu
- Bioethanol production from alkaline-pretreatmented sugarcane bagasse by consolidated bioprocessing using Phlebia sp. MG-60
International Biodeterioration & Biodegradation, ,88, 62-68(2014)
L. D. Khuong, R. Kondo, R. D. Leon, T. K. Anh, K. Shimizu, I. Kamei
- Antioxidant and anti-melanogenesis activities of an extract of the Indonesian
Lai fruit (Durio kutejensis)
Tropical Journal of Pharmaceutical Research, 14(1) 41-46(2015)
E.T. Arung, W. Suwinarti, M. Hendra, Supomo, I. W. Kusuma, D. C. N. Puteri,
H. A. Eroglu, Y-U, Kim, K. Shimizu, H. Ishikawa
- Lipoxygenase inhibitory activity of alkyl protocatechuates
Food Chemistry, 159, 471-476 (2014)
T. J. Ha, K. Shimizu, I. Kubo
- Production of citric acid from corncobs with its biological evaluation
Journal of Cosmetics, Dermatological Sciences and Applications, 4, 141-149(2014)
A. Ashour, S. EI-Sharkawy, M. Amer, A. Marzouk, A. Kishikawa, M. Ohzono, R. Kondo, K. Shimizu
- Biodegradation of heptachlor-contaminated soil by white-rot fungal inocula
Environmental Science and Pollution Research, 21(19), 11305-11312, 2014
A.S. Purnomo, E. M. M. Putri, R. Nawfa, S. R. Putra, K. Shimizu, R. Kondo
- Effect of chemical factors on integrated fungal fermentation of
sugarcane bagasse for ethanol production by a white-rot fungus,
Phlebia sp. MG-60
Bioresource Technology 167C, 33-40, 2014
L. D. Khuong, R. Kondo, R. D. Leon, T. K. Anh, K. Shimizu, I. Kamei
- Potent Angiotensin-Converting Enzyme Inhibitory Tripeptides identified
by a Computer-based Approach
Journal of Molecular Graphics and Modeling, 53, 206-211, 2014
DOI: 10.1016/j.jmgm.2014.08.002
T. H. Bang, K. Shimizu
- 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng
Bioorganic & Medicinal Chemistry Letters 24(18) 4407-4409, 2014
S. Fatmawati, H. Yu, C. Zhang, F. Jin, K. Shimizu
DOI information: 10.1016/j.bmcl.2014.08.009
- The inhibitory activity of aldose reductase in vitro by constituents of
Garcinia mangostana Linn.
Phytomedicine, 22(1), 49-51, 2015
S. Fatmawati, T. Ersama, K. Shimizu
- In vitro bioactivities and phytochemical profile of various parts of the strawberry
(Fragaria×ananassa var. Amaou)
Journal of Functional Foods, 13(1)38-49, 2015
Q. Zhu, T. Nakagawa, A. Kishikawa, K. Ohnuki, K. Shimizu
- Multiple biological effects of olive oil by-products such as leaves, stems, flowers, olive milled waste, fruit pulp, and seeds of the olive plant on skin.
Phytotherapy Research, 29(6)877-866, 2015
A. Kishikawa, A. Ashour, Q. Zhu, M. Yasuda, H. Ishikawa, K. Shimizu
DOI: 10.1002/ptr.5326
- Structure-Activity Relationship and Inhibition Pattern of Reishi-derived
(Ganoderma lingzhi) Triterpenoids against Angiotensin-Converting Enzyme
Phytochemistry Letters, 12, 243-247, 2015
T. H. Bang, K. Shimizu
- A structure-activity relationship study on antiosteoclastogenesis effect
of triterpenoids from the leaves of loquat (Eriobotrya japonica)
Phytomedicine, 22(4), 498-503, 2015
H. Tan, A. Ashour, Y. Katakura, K. Shimizu
DOI: 10.1016/j.phymed.2015.03.002
- Kibizu concentrated liquid suppresses the accumulation of lipid droplets in 3T3-L1 cells
Cytotechnology, 64(4)721-725, 2015
C. Inoue,T. Kozaki,Y. Morita,B. Shirouchi, K. Fukami, K.Shimizu, M. Sato,Y.
Katakura
- Determination of Seed Soundness inConifers Cryptomeria japonicaand Chamaecyparis
obtusaUsing Narrow-Multiband Spectral Imaging in the Short-Wavelength Infrared
Range
PLOS ONE, 10(6), 2015, e0128358
O. Matsuda, M. Hara, H. Tobita, K. Yazaki, T. Nakagawa, K. Shimizu, A. Uemura, H. Utsugi
- Biological activities of oleanolic acid derivatives from Calendula officinalis Seeds.
Phytotherapy Research, 30(5):835-41, 2016
A. Zaki, A. Ashour, A. Mira, A. Kishikawa, T. Nakagawa, Q. Zhu, K. Shimizu
- Improved Biological Activities of Isoepoxypteryxin by Biotransformation
Chemistry & Biodiversity, 13:1-9, 2016
A. Mira, W. Alkhiary, Q. Zhu, T. Nakagawa, H.B. Tran, Y. M. Amen and K.
Shimizu
- Antiplatelet and Anticoagulant Activities of Angelica shikokiana Extract and its Isolated Compounds
Clinical and Applied Thrombosis/Hemostasis, 23(1)91-99, 2017
doi: 10.1177/1076029615595879
A. Mira, W, Alkhiary, K. Shimizu.
- Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design
Scientific Reports
DOI: 10.1038/srep13194.
Q. Zhu, T. H. Bang, K. Ohnuki, T. Sawai, K. Sawai, K. Shimizu
- Multiple uses of essential oil and by-products from various parts of the
Yakushima native cedar (Cryptomeria japonica)
Journal of Wood Chemistry and Technology, 36(1)42-55 (2016)
T. Nakagawa, Q. Zhu, H. Ishikawa, K. Ohnuki, K. Kakino, N. Horiuchi, H.
Shinotsuka, T. Naito, T. Matsumoto, N. Minamisawa, M. Yatagai, K. Shimizu
- Biological activities of extracts from different parts of Cryptomeria japonica
Natural Product Communications, in press
H. Horiba, T. Nakagawa, Q. Zhu, A. Ashour, A. Watanabe, K. Shimizu
- In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and Its isolated compounds
Pharmacognosy Magazine, 11(44)(S4)S564-569 (2016)
A. Mira, K. Shimizu
- In Vitro Neuroprotective Activities of Compounds from Angelica shikokiana Makino
Molecules 20(3), 4813-4832, 2015
A. Mira, S. Yamashita, Y. Katakura, K. Shimizu
doi:10.3390/molecules20034813
- Biodegradation of aldrin and dieldrin by the white-rot fungus Pleurotus ostreatus
Current Microbiology, 74, 320-324, 2017
A.S. Purnomo, R Nawfa, F. Martak, K. Shimizu, I. Kamei
- Tubulin polymerization stimulating-activity of Ganoderma triterpenoids
Journal of Natural Medicines, 71(2), 457-462, 2017
T. Kohno, T. Hai-Bang, Q. Zhu, Y. Amen, S. Sakamoto, H. Tanaka, S. Morimoto, K. Shimizu
- Lucidumol C, a new lanostanoid triterpene from Ganoderma lingzhi with potential activity against colon cancer
Journal of Natural Medicines (2016) in press
Yhiya M. Amen, Amira Mira, Hai-Bang Tran, Mohamed S. Afifi, Ahmed F. Halim,
Ahmed Ashour, Kuniyoshi Shimizu
- Anti-proliferative Activity of Some Oleanolic acid derivatives with Potent
TopoisomeraseInhibitory Activity on B16 Melanoma Cells
Wood Research Journal, Vol/ 6, No. 1(2015) in press
Ahmed Ashour, Ryuichiro Kondo, and Kuniyoshi Shimizu.
- Methoxyflavones from Ganoderma lingzhi
International Journal of Medicinal Mushrooms (2016) in press
Yhiya M. Amen, Satoru Kaifuchi, Kuniyoshi Shimizu.
- Anti-choline esterase activity of ceramides from the Red Sea Marine Sponge
Mycale euplectellioides
RSC Advances 6, 20422-20430(2016)
Reda Abdelhameed,Mohamed Saleh Elgawish,Amira Mira, Amany K. Ibrahim, Safwat
A. Ahmed, Kuniyoshi Shimizu,Koji Yamada
- Simultaneous determination of four vasoactive phytochemicals in different pharmaceutical preparations by a simple HPLC-DAD method
Analytical Methods, 8, 1858-1866(2016)
F. Ibrahim, M. K. S. El-Din, R. N. El-Shaheny, A. K. El-Deen, K. Shimizu
- Detection of ganoderic acid A in Ganoderma lingzhi by an indirect competitive enzyme-linked immunosorbent assay
Planta Med.82(8):747-51(2016)
Sakamoto, S., Kohno, T., Shimizu, K., Tanaka, H., Morimoto, S.
- An LC-MS/MS-SRM method for simultaneous quantification of four representative
organosulfur compounds in garlic products
Food Analytical Methods 9(12), 3378-3384(2016)
Q. Zhu., K. Kakino, C. Nogami, K. Ohnuki, K. Shimizu.
- Anti-oxidative Activities of 62 Wild Mushrooms from Nepal and the Phenolic
Profile of Some Selected Species
Journal of Natural Medicines, 70, 769-779(2016)
S. Tamrakar, H. B. Tran, M. Nishida, S. Kaifuchi, H. Suhara, K. Doi, K.
Fukami, G. P. Parajuli, K. Shimizu
- Hericium erinaceus extracts alter behavioral rhythm in mice
Biomedical Research, 37(4)227-232(2016)
S. Furuta, R. Kuwahara, E. Hiraki, K. Ohnuki, S. Yasuo, K. Shimizu
- Acetyl choline esterase inhibitors and melanin synthesis inhibitors from
Salvia officinalis
Phytomedicine (2016) in Press
A. Sallam, A. Mira, A. Ashour, K. Shimizu
-
New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Phytochemistry Letters, 64-70, 2016
Y. M. Amen, Q. Zhu, M. S. Afifi, A. F. Halim, A. Ashour, K. Shimizu
- Micellar HPLC method for simultaneous determination of ethamsylate and
mefenamic acid in presence of their main impurities and degradation products
Journal of Chromatographic Science, in press
F. Ibrahim, M. K. S. El-Din, A. K. El-Deen, K. Shimizu
- Immunochromatographic strip assay for detection of bioactive Ganoderma
triterpenoid, ganoderic acid A in Ganoderma lingzhi
Fitoterapia, 114, 51-55(2016)
S. Sakamoto, N. Kikkawa,T. Kohno, K. Shimizu, H. Tanaka,S. Morimoto
- An Eco-friendly Green Liquid Chromatographic Method for Simultaneous Determination
of Nicotinamide and Clindamycin phosphate in Pharmaceutical Gel for Acne
Treatment
Journal of Food and Drug Analysis, in press
F. Ibrahim, A. K. El-Deen, S. A. El Abass, K. Shimizu
- A phenolic acid and its antioxidant activity from stem bark of chloroform
fraction of Syzygium littorale (Blume) amshoff (Myrtaceae)
Molekul, 11(2)180-189(2016)
Tukiran, F. Mahmudah, N. Hidayati, K. Shimizu
- Antioxidant activity of Moringa oleifera extracts
Indones. J. Chem. 16(3)297-301(2016)
W.D. Ditriana, T. Ersam, K. Shimizu, S. Fatmawati
- Anti-allergic triterpenes isolated from olive milled waste
Cytotechnology, 69(2), 307-315(2017)
A. Kishikawa, Y. Amen, K. Shimizu
- Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds; Insights on discovery of natural Rho-kinase
inhibitors
Journal of Natural Medicines, in press
Yhiya Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S. Afifi, Ahmed F. Halim,
Ahmed Ashour, Kuniyoshi Shimizu
- Synthesis, Docking, Cytotoxicity, and LTA4H Inhibitory Activity of New
Gingerol Derivatives as Potential Colorectal Cancer Therapy
Bioorganic & Medicinal Chemistry, in press
Mai H. El-Naggar, Amira Mira, Fatma M. Abdel Bar, Kuniyoshi Shimizu, Mohamed
M. Amer, Farid A. Badria
- Anti-obesity activity of Yamabushitake (Hericium erinaceum) powder on
ovariectomized mice and its potentially active compounds
Journal of Natural Medicines, in press
Eri Hiraki, Shoko Furuta, Rika Kuwahara, Naomichi Takemoto,
Toshiro Nagata, Taiki Akasaka, Bungo Shirouchi, Masao Sato,
Koichiro Ohnuki, Kuniyoshi Shimizu
- Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells
Natural Product Research, in press
Yhiya Amen, Enos Tangke Arung, Mohamed S. Afifi, Ahmed F. Halim, Ahmed
Ashour, Ryoji Fujimoto, Takahiro Goto and Kuniyoshi Shimizu
- Anti-influenza effects of Ganoderma lingzhi: an animal study
Journal of Functional Foods, in press
Qinchang Zhua, Yhiya Amen, Koichiro Ohnuki, Kuniyoshi Shimizu
- An Active
Drimane-Type Lactone from Polygonum jucundum Attenuates
Lipopolysaccharide-Induced Acute Lung Injury in Mice Through TLR4-MAPKs
Signaling Pathway
Inflammation, 40(1)1204-1213 (2017)
Yang Hu, Lijun
Tao, Hui Tan, Mian Zhang, Kuniyoshi Shimizu, Fei Zhang, Chaofeng Zhang
-
The potential of triterpenoids from loquat leaves (Eriobotrya
japonica) for prevention and treatment of skin disorder
International Journal of Molecular Sciences, in press
H. Tan, T. Sonam, K. Shimizu
- Antibacterial activity of Nepalese wild mushrooms against Staphylococcus aureus and Propionibacterium acnes
Journal of Wood Science, in press
S. Tamrakar, M. Nishida, Y. Amen, H. B. Tran, H. Suhara, K. Fukami, G.
P. Parajuli, K. Shimizu
- Erratum to: Biodegradation of Aldrin and Dieldrin by the White-Rot Fungus
Pleurotus ostreatus
Current Microbiology, 1, 2017
A.S. Purnomo, R Nawfa, F. Martak, K. Shimizu, I. Kamei
- Antioxidant activity of Syzygium polynthum extract
Indonesian Journal of Chemistry, 17(1)49-53, 2017
Hidayati, M.D., Ersam, T., Shimizu, K., Fatmawati, S.
- Rho-kinase inhibitors from Adlay seeds
Natural Prodct Research (in press)
Y. Amen, Q. Zhu, H.-B. Tran, M. S. Afifi, A.F. Halim, A. Ashour, R. Fujimoto, .T. Goto, K. Shimizu
- Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and human plasma: Application to degradation kinetics
Journal of Food and Drug Analysis (in press)
M.K.S. El-Din, F. Ibrahim, A. K. El-Deen,K. Shimizu
- Effect of polyphenols fromVicia faba on lipase activity and melanogenesis
Natral Prodct Research (in press)
A.E. Allam, A.M. Nafady, T. Nakagawa, K. Shimizu
- Hepatoprotective Activities of The Methanol Extract of Angelica shikokiana
and its major coumarin: Isoepoxypteryxin against Hepatocellular Carcinoma
Indian Journal of Pharmaceutical Sciences, 79(4)576-584 (2017)
A. Mira, N. Elsherbiny, W. Alkhiary, A. Shebl, H. Tran AND K. Shimizu
- Application of Quinone-based Fluorophore and Native Fluorescence for the Spectrofluorimetric Determination of Agomelatine in Dosage Form: Identification of Acidic and Alkaline- Induced Degradation Products by LC-MS/TOF
Luminescence: The Journal of Biological and Chemical Luminescence
F. Ibrahim, A.K. El-Deen, K. Shimizu (in press)
- Bacterial expression of a single-chain variable fragment (scFv) antibody
against ganoderic acid a: A cost-effective approach for quantitative analysis
using the scfv-based enzyme-linked immunosorbent assay
Biological and Pharmaceutical Bulletin, 40(10) pp. 1767-1774(2017)
Yusakul G., Nuntawong P., Sakamoto S., Bhuket P.R.N., Kohno T., Kikkawa N., Rojsitthisak P., Shimizu K., Tanaka H., Morimoto S.
- Forsskamide, A New Ceramide from Aerial Parts of Forsskaole
Natural Product Research, in press
H.K. Assaf, A.M. Nafady, A. E. Allam, A.N.E. Hamed, M.S. Kamel, K. Shimizu
- Anti-angiogenic activity of rotenoids from the stems of Derris trifoliata
Planta Medica, in press
Y. Mittraphab, N. Ngamrojanavanich, K. Shimizu, K. Matsubara, K. Pudhom
- Potential activities for constituents from Vicia faba
Trends in Phytochemical Research, in press
A. Allam, A. Nafady, A.I.M. A. Khedr, T. Nakagawa, K. Shimizu
- Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi
(Ganoderma lingzhi)
Natural Product Research, in press
D. Satria, Y. Amen, Y. Niwa, A. Ashour, A. E. Allam, K. Shimizu
- Comparative study of two different chromatographic approaches for quantification of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Journal of Food and Drug Analysis, in press
F. Ibrahim, A.K. EI-Deen, K. Shimizu
- Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits
HSC activation through downregulating TLR4-mediated pathways
International Immunopharmacology, 55, 183-192(2018)
F. Cao, Y. Zhang, W. Li, K. Shimizu, H. Xie, C. Zhang
- Changes in triterpenoids and polysaccharides content in Ganoderma lingzhi
at different growth stages
Journal of Natural Medicines, in press
T. Nakagawa, Q. Zhu, S. Tamrakar, Y. Amen, Y. Mori, H. Suhara, S. Kaneko,
H. Kawashima, K. Okuzono, Y. Inoue, K. Ohnuki, K. Shimizu
受賞
清水 准教授 業績一覧
